SAT-595 Early Weight Gain Impact onto the Arcuate Leptin Receptor Expressing Neurons Activity During Development
نویسندگان
چکیده
منابع مشابه
Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults.
OBJECTIVE To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain. RESEARCH METHODS AND PROCEDURES From two large prospective cohorts in The Netherlands (n = 17,500), we compared the baseline leptin of 259 subjects who had gained an average of 12.6 kg (range 5.5 to 33 kg) with 277 subjects who kept stable weight (range -2.6 to 3....
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Anthropometric parameters are an important indicator of health and nutritional status comprising the whole span of mans life. However, they are not of the same degree of simplicity and sensitivity in assessing the public health status. During recent decades many studies have attempted to examine the relationships of these measurements in order to present simple alternatives for similar purposes...
متن کاملAppropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.
Leptin directly suppresses the activity of orexigenic neurons in the hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity (CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin receptor (LRb) and s/s mice that express LRb(S1138) [which is defective for STAT3 (signal transducer and activator of transcription) signaling]. Both ...
متن کاملDevelopment of hyperinsulinemia and insulin resistance during the early stage of weight gain.
Obesity is associated with insulin resistance and hyperinsulinemia, which is considered to be a core component in the pathophysiology of obesity-related comorbidities. As yet it is unknown whether insulin resistance and hyperinsulinemia already develop during weight gain within the normal range. In 10 healthy male subjects the effect of intentional weight gain by 2 BMI points was examined on in...
متن کاملAblation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation.
RATIONALE The hypothalamic arcuate nucleus (ARC) is considered a major site for leptin signaling that regulates several physiological processes. OBJECTIVE To test the hypothesis that leptin receptor in the ARC is required to mediate leptin-induced sympathetic activation. METHODS AND RESULTS First, we used the ROSA Cre-reporter mice to establish the feasibility of driving Cre expression in t...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa046.1759